Tardive dyskinesia with clozapine dose reduction or withdrawal dyskinesia?

Relapse of tardive dyskinesia due to reduction in clozapine dose

Clozapine is a second-generation (atypical) antipsychotic agent, which has been proven efficient against the positive and negative symptoms of schizophrenia, with a low propensity to induce tardive dyskinesia (TD). Compared with typical antipsychotics, it has a greater affinity for dopamine D4 than D2 receptors and additional action on serotonin 5-HT(2A) receptors. Due to its weak D(2) blocking...

Clozapine-induced Tardive Dyskinesia

Resolution of Tardive Dyskinesia with Clozapine: A Case Report

Tardive dyskinesia is an extrapyramidal side effect that can occur after a prolonged use of antipsychotic medication, it appears to be about 0.4% to 4% worldwide. Prior reports suggest that clozapine may be effective in the management of tardive dyskinesia. We present the case of a patient with tardive dyskinesia induced by antipsychotics. After treatment failure with other psychotropic medicat...

Low Dose Levodopa in Tardive Dyskinesia

Efficacy of low dose levodopa in treatment of TD has been studied on 30 male inpatients with predefined selection criteria. The preliminary results are encouraging but long term double blind studies in larger samples are needed.

Anosognosia in tardive dyskinesia: "tardive dysmentia" or "tardive dementia"?

Wilson et al. (1983) called attention to the increasing incidence of affective symptomatology in schizophrenic patients on chronic neuroleptic medication. They designated the emerging syndrome as tardive dysmentia in order to emphasize its connection with the pathophysiology of tardive dyskinesia. The present contribution suggests that the emotional indifference or frank anosognosia of abnormal...